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Table of Contents
Check if there is a USB interface power supply or connection problem
Update or reinstall the mouse driver
View system settings or software conflicts
Finally consider hardware issues
Home Computer Tutorials Troubleshooting how to fix mouse not working in one usb port

how to fix mouse not working in one usb port

Jul 14, 2025 am 12:34 AM

When the mouse is not working, you should first check the interface power supply or contact problems, try to replace the native interface on the back of the motherboard, clean the interface or adjust the power management settings; secondly update or reinstall the mouse driver, and eliminate software conflicts; finally confirm whether it is a hardware failure. Specific steps include: 1. Replace the USB interface test to avoid using the hub; 2. Clean the interface dust or oxides; 3. Turn off the USB selective pause settings; 4. Update or reinstall the driver; 5. Test other mice to distinguish the source of the problem; 6. Turn off third-party software that may be interfered with; 7. Test the mouse in safe mode; 8. Check the operating status of the HID service; 9. Test the interface's support for other devices; 10. Check the BIOS settings or consider hardware repairs.

how to fix mouse not working in one usb port

The mouse does not work on a USB port, which is actually quite common. Possible causes include problems with the interface itself, driver exceptions or mouse hardware problems. Don't rush to change the motherboard or mouse, in most cases, you can troubleshoot and solve it.

how to fix mouse not working in one usb port

Check if there is a USB interface power supply or connection problem

Some USB interfaces are insufficient power supply or poor physical contact, which will cause the peripherals to fail to operate normally. This problem is more likely to occur when interfaces on front panels or expansion hubs.

  • Try plugging the mouse into other USB ports, especially the native port on the back of the motherboard
  • If you are using a USB hub, try plugging it directly into the computer to see if there is any improvement
  • Sometimes dust or oxidation can also cause poor contact, and you can use a cotton swab to clean the interface gently.

In addition, some computers will automatically turn off power supply to some USB interfaces in the power saving settings. You can check whether "USB Selective Suspend" is turned on in the power management settings and try to turn it off.

how to fix mouse not working in one usb port

Update or reinstall the mouse driver

Even if the mouse looks OK, a driver corruption can cause failure only on certain interfaces.

  • Open Device Manager and find "Mouse and Other Pointer Devices"
  • Right-click on your mouse device and select "Update Driver"
  • If it doesn't work, you can try uninstalling and re-pluging and uninstalling the mouse to allow the system to automatically install

If you are not sure if it is a driver problem, you can also try to plug in the USB port with a mouse to see if there is any similar situation. If there is a problem with another mouse, it is basically an interface or system level problem.

how to fix mouse not working in one usb port

View system settings or software conflicts

Sometimes third-party software (such as mouse enhancement tools, gaming platforms) may interfere with the recognition of USB devices.

  • Close some optimization software running in the background, and try plugging and unplugging the mouse
  • Test whether the mouse can be used normally in safe mode, which can eliminate most software interference

In addition, if the Windows HID (Human-Machine Interface Device) service is disabled, it may also affect the recognition of the USB mouse. You can check whether the Human Interface Device Access service is running in the Services application.


Finally consider hardware issues

If you try all the above methods but still don't work, it may be that the interface itself is broken. At this time you can:

  • Check whether the USB interface supports other devices, such as keyboards, USB disks, etc.
  • If only the mouse does not work, it may be that the interface recognizes abnormalities in low-power devices.
  • If there are USB-related options in the motherboard BIOS settings, you can also try to restore the default settings.

If it is a desktop computer, you can try to replace another USB socket; if you want to repair the laptop, it is recommended to check whether the motherboard interface is falsely soldered or damaged.

Basically, these are the directions of investigation. Although the steps seem a bit too many, most of the time it can be done in a few minutes.

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