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Start two uwsgi on different ports. Note that the logs and pid are also separated.

You are mainly not familiar with nginx configuration. In fact, just add a server paragraph:

    server {
        listen       80;
        server_name  A的域名;

        location / {
            include uwsgi_params;
            uwsgi_pass 127.0.0.1:A的uwsgi端口; 
            root   html;
            index  index.html index.htm;
        }
    }
    server {
        listen       80;
        server_name  B的域名;

        location / {
            include uwsgi_params;
            uwsgi_pass 127.0.0.1:B的uwsgi端口; 
            root   html;
            index  index.html index.htm;
        }
    }